49ers @ Steelers 1:00 PM ET
Game# 465-466
Play On: Steelers +2.5

Under head coach Kyle Shanahan. The 49ers are just 2-4 SU and 1-5 ATS in season openers. That includes 0-2 SU&ATS as a favorite of 7.0 or less. As a matter of fact, San Francisco dropped their season opener last season while suffering a 19-10 loss at Chicago in a game they close as a 6.5-point favorite, and versus a Bears team that finished the 2022-2023 season 3-14. Pittsburgh is 3-0 SU&ATS in their last 3 season openers under current head coach Mike Tomlin. Pittsburgh is also 6-0 SU&ATS in their last 6 at home when there was a total of 37.0 or greater and their point-spread was +2.5 to -2.5.

Since 2009, Game 1 NFL division home underdogs of 5.5 or less like Pittsburgh, and they won 3 games or more in the previous season, resulted in those season opener division home underdogs going 16-2 ATS, and they won 15 of those 18 contests straight up. Give me the Steelers plus points.