Louisville: The Cardinals opened the season as the nation's 19th-ranked team and its 70-14 win over outclassed Charlotte (coupled with a myriad of losses by other ranked teams) has the team at No. 13 in the latest AP poll. Sophomore QB Lamar Jackson delivered a record-setting season debut vs. Charlotte. He accounted for eight touchdowns (including six TD passes) in a mere one-half's worth of work. Both of those marks tied ACC records and set new school records, prompting head coach Bobby Petrino to say afterward: "It was nice to get everybody involved. He read the coverage and delivered the ball, and let the players make the plays for you." Louisville racked up 663 yards of total offense (38 FDs), as 16 different players ended up catching a pass as the team posted its largest margin of victory in a season opener since 2007. Louisville also held Charlotte to 0-of-13 on third-down conversions, while the 49ers gained just 208 yards on 12 FDs.

Syracuse: The Orange are coming off a 33-7 win over FCS team Colgate in the school's first game under new coach Dino Babers. Babers began his head coaching career at Eastern Illinois (two playoff appearances in two seasons) before taking the Bowling Green job. He was 18-9 in two seasons, leading the Falcons to back-to-back bowl berths (did not coach in last year's bowl game, after leaving for to take the Syracuse job). Syracuse QB Eric Dungey delivered 355 passing yards and two TDs against Colgate while combining with Zack Mahoney to complete 40-of-46 passes for the entire game.

The pick: The Orange had 81 plays for 554 yards in total offense in beating Colgate last week but now step way up in class against a Louisville "D" which allowed just 208 yards on opening weekend. As for Louisville, the Cardinals now take to the road and off the the team's 70-point outburst, could find the going much tougher against a Syracuse defense which returns its top seven tacklers from 2015. Dino Babers gave a call to arms of sorts during his weekly news conference Monday morning when asked about what he think of a crowd size just north of 30,000 vs. Colgate. "I thought it was kind of loud, and we've got room for another 18-19,000 people to get in there," Babers said. "I think it can get really loud. We need all the fans to show up in orange, and we need to see a sea of orange out there. Loud when Lamar and Louisville have the ball and quiet when we have the football. If we can get that, it'll be a heck of a home-field advantage, and we're going to need all the help we can." Syracuse has planned an 'Orange Out' for this Friday night game with Louisville, encouraging all fans to wear orange to the game. The under is a 10* play.